Linda J.Van Eldik: search on Z-Library

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1

The p38α mitogen-activated protein kinase as a central nervous system drug discovery target

Aaron S Borders, Lucia de Almeida, Linda J Van Eldik, D Martin Watterson

Journal:

BMC Neuroscience

Year:

2008

Language:

english

File:

PDF, 1.37 MB

english, 2008

2

Identification of the binding site on S100B protein for the actin capping protein CapZ

Peter M. Kilby, GORDON C. K. Roberts, Linda J. Van Eldik

Journal:

Protein Science

Year:

1997

Language:

english

File:

PDF, 3.74 MB

english, 1997

3

Immunohistochemical localization of the S-100β protein in postnatal cat visual cortex: spatial and temporal patterns of expression in cortical and subcortical glia

Richard H. Dyck, Linda J. Van Eldik, Max S. Cynader

Journal:

Developmental Brain Research

Year:

1993

Language:

english

File:

PDF, 2.64 MB

english, 1993

4

Early-to mid-life formal training in music is associated with improved late-life semantic and episodic memory among cognitively normal older adults

Abner, Erin, Schmitt, Frederick, Kryscio, Richard, Jicha, Gregory, Cooper, Gregory, Smith, Charles, Fardo, David, Van Eldik, Linda, Gooding, Lori

Journal:

Alzheimer's & Dementia

Year:

2013

Language:

english

File:

PDF, 48 KB

english, 2013

5

Effects of advanced age upon astrocyte-specific responses to acute traumatic brain injury in mice

Early, Alexandria N., Gorman, Amy A., Van Eldik, Linda J., Bachstetter, Adam D., Morganti, Josh M.

Journal:

Journal of Neuroinflammation

Year:

2020

File:

PDF, 5.55 MB

2020

6

Increased susceptibility of S100B transgenic mice to perinatal hypoxia-ischemia

Mark S. Wainwright, Jeffrey M. Craft, W. Sue T. Griffin, Alexander Marks, Jose Pineda, Kyle R. Padgett, Linda J. Van Eldik

Journal:

Annals of Neurology

Year:

2004

Language:

english

File:

PDF, 266 KB

english, 2004

7

S100β Increases Levels of β-Amyloid Precursor Protein and Its Encoding mRNA in Rat Neuronal Cultures

Yuekui Li, Jianzhong Wang, Jin G. Sheng, Ling Liu, Steven W. Barger, Richard A. Jones, Linda J. Van Eldik, Robert E. Mrak, W. Sue T. Griffin

Journal:

Journal of Neurochemistry

Year:

1998

Language:

english

File:

PDF, 1.46 MB

english, 1998

8

Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα

Bin Xing, Adam D Bachstetter, Linda J Van Eldik

Journal:

Molecular Neurodegeneration

Year:

2011

Language:

english

File:

PDF, 721 KB

english, 2011

9

Structure and enzymology of a death-associated protein kinase

Linda J Van Eldik

Journal:

Trends in Pharmacological Sciences

Year:

2002

Language:

english

File:

PDF, 66 KB

english, 2002

10

Apolipoprotein E and apolipoprotein E receptors modulate Aβ-induced glial neuroinflammatory responses

Mary Jo LaDu, Javeed Ali Shah, Catherine A Reardon, Godfrey S Getz, Guojun Bu, Jingru Hu, Ling Guo, Linda J Van Eldik

Journal:

Neurochemistry International

Year:

2001

Language:

english

File:

PDF, 554 KB

english, 2001

11

Similar activation of glial cultures from different rat brain regions by neuroinflammatory stimuli and downregulation of the activation by a new class of small molecule ligands

Ling Guo, Anu Sawkar, Magdalena Zasadzki, D.Martin Watterson, Linda J Van Eldik

Journal:

Neurobiology of Aging

Year:

2001

Language:

english

File:

PDF, 271 KB

english, 2001

12

Apolipoprotein E and its receptors mediate the effects of β-amyloid-induced inflammation in primary astrocyte cultures

Mary Jo LaDu, Javeed Ali Shah, Catherine A. Reardon, Godfrey S. Getz, Guojun Bu, Jingru Hu, Linda J. Van Eldik

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 376 KB

english, 2000

13

Rapid separation and quantitation of 3′,5′-cyclic nucleotides and 5′-nucleotides in phosphodiesterase reaction mixtures using high-performance liquid chromatography

D.Martin Watterson, David B. Iverson, Linda J. Van Eldik

Journal:

Journal of Biochemical and Biophysical Methods

Year:

1980

Language:

english

File:

PDF, 620 KB

english, 1980

14

Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a ‘two-hit’ seizure model

Kathleen C. Somera-Molina, Sangeetha Nair, Linda J. Van Eldik, D. Martin Watterson, Mark S. Wainwright

Journal:

Year:

2009

Language:

english

File:

PDF, 1.64 MB

english, 2009

15

Interaction of calmodulin and other calcium-modulated proteins with mammalian and arthropod junctional membrane proteins

Linda J. Van Eldik, Elliot L. Hertzberg, Robert C. Berdan, Norton B. Gilula

Journal:

Biochemical and Biophysical Research Communications

Year:

1985

Language:

english

File:

PDF, 1.26 MB

english, 1985

16

Differential effects of oligomeric and fibrillar amyloid-β1–42 on astrocyte-mediated inflammation

Jill A. White, Arlene M. Manelli, Kristina H. Holmberg, Linda J. Van Eldik, Mary Jo LaDu

Journal:

Neurobiology of Disease

Year:

2005

Language:

english

File:

PDF, 481 KB

english, 2005

17

[Principles of Medical Biology] Molecular and Cellular Genetics Volume 5 || Chapter 8 Antisense RNA and DNA as potential therapeutic agents

Van Eldik, Linda J.

Year:

1996

Language:

english

File:

PDF, 726 KB

english, 1996

18

TARGETING NEUROINFLAMMATION IN THE CONTEXT OF ALZHEIMER’S DISEASE WITH COMORBID VASCULAR PATHOLOGY

Braun, David J., Wilcock, Donna M., Van Eldik, Linda J.

Journal:

Alzheimer's & Dementia

Year:

2018

Language:

english

File:

PDF, 117 KB

english, 2018

19

Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human β-amyloid in a murine model of neuroinflammation

Jeffrey M. Craft, Linda J. Van Eldik, Magdalena Zasadzki, Wenhui Hu, D. Martin Watterson

Journal:

Journal of Molecular Neuroscience

Year:

2004

Language:

english

File:

PDF, 98 KB

english, 2004

20

Elucidation of a minimal immunoreactive site of vertebrate calmodulin

Linda J. Van Eldik, D.Martin Watterson, Kam-Fook Fok, Bruce W. Erickson

Journal:

Archives of Biochemistry and Biophysics

Year:

1983

Language:

english

File:

PDF, 1005 KB

english, 1983

21

Conditions for reproducible detection of calmodulin and S100β in immunoblots

Linda J. Van Eldik, Sandra R. Wolchok

Journal:

Biochemical and Biophysical Research Communications

Year:

1984

Language:

english

File:

PDF, 468 KB

english, 1984

22

Myosin light chain kinase (210 kDa) is a potential cytoskeleton integrator through its unique N-terminal domain

Dmitry S Kudryashov, Olga V Stepanova, Elena L Vilitkevich, Tatyana A Nikonenko, Elena S Nadezhdina, Nina A Shanina, Thomas J Lukas, Linda J Van Eldik, D.Martin Watterson, Vladimir P Shirinsky

Journal:

Experimental Cell Research

Year:

2004

Language:

english

File:

PDF, 787 KB

english, 2004

23

Cytokine Up-Regulation as a Contributor to CNS Pathophysiology

Linda Van Eldik

Journal:

Alzheimer's & Dementia

Year:

2011

Language:

english

File:

PDF, 44 KB

english, 2011

24

Inhibition of protein kinase C- and casein kinase II-mediated phosphorylation of GAP-43 by S100β

Li-Hsien Lin, Linda J. Van Eldik, Neil Osheroff, Jeanette J. Norden

Journal:

Molecular Brain Research

Year:

1994

Language:

english

File:

PDF, 889 KB

english, 1994

25

MCP-1-deficient mice show reduced neuroinflammatory responses and increased peripheral inflammatory responses to peripheral endotoxin insult

Wendy L Thompson, William J Karpus, Linda J Van Eldik

Journal:

Journal of Neuroinflammation

Year:

2008

Language:

english

File:

PDF, 2.64 MB

english, 2008

26

[Part 2: Biological Sciences] || Calcium-Dependent Interaction of S100b, Troponin C, and Calmodulin with an Immobilized Phenothiazine

Daniel R. Marshak, D. Martin Watterson and Linda J. Van Eldik

Journal:

Proceedings of the National Academy of Sciences

Year:

1981

Language:

english

File:

PDF, 1.10 MB

english, 1981

27

[International Review of Cytology] International Review of Cytology Volume 77 Volume 77 || Calcium-Binding Proteins and the Molecular Basis of Calcium Action

Van Eldik, Linda J.

Year:

1982

Language:

english

File:

PDF, 3.49 MB

english, 1982

28

An optimized and isoform-selective p38aMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models

Van Eldik, Linda J., Roy, Saktimayee M., Watterson, D. Martin, Arancio, Ottavio

Journal:

Alzheimer's & Dementia

Year:

2015

Language:

english

File:

PDF, 43 KB

english, 2015

29

Correction to âA Selective and Brain Penetrant p38Î±MAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunctionâ

Roy, Saktimayee M., Minasov, George, Arancio, Ottavio, Chico, Laura W., Van Eldik, Linda J., Anderson, Wayne F., Pelletier, Jeffrey C., Watterson, D. Martin

Journal:

Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 337 KB

2020

30

Activated glia induce neuron death via MAP kinase signaling pathways involving JNK and p38

Zhong Xie, Carolyn J. Smith, Linda J. Van Eldik

Journal:

Year:

2004

Language:

english

File:

PDF, 766 KB

english, 2004

31

S100β protects hippocampal neurons from damage induced by glucose deprivation

Steven W. Barger, Linda J. Van Eldik, Mark P. Mattson

Journal:

Year:

1995

Language:

english

File:

PDF, 376 KB

english, 1995

32

Modulation of glial activation by astrocyte-derived protein S100B: differential responses of astrocyte and microglial cultures

Tatiana V. Petrova, Jingru Hu, Linda J. Van Eldik

Journal:

Year:

2000

Language:

english

File:

PDF, 175 KB

english, 2000

33

Aminopyridazines inhibit β-amyloid-induced glial activation and neuronal damage in vivo

Jeffrey M. Craft, D.Martin Watterson, Sally A. Frautschy, Linda J.Van Eldik

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 249 KB

english, 2004

34

Ligand modulation of glial activation: cell permeable, small molecule inhibitors of serine-threonine protein kinases can block induction of interleukin 1β and nitric oxide synthase II

D.Martin Watterson, Salida Mirzoeva, Ling Guo, Authrine Whyte, Jean-Jacques Bourguignon, Marcel Hibert, Jacques Haiech, Linda J Van Eldik

Journal:

Neurochemistry International

Year:

2001

Language:

english

File:

PDF, 189 KB

english, 2001

35

Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1β production

Seon H. Kim, Carolyn J. Smith, Linda J. Van Eldik

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 315 KB

english, 2004

36

P2-419: Development of novel protein kinase inhibitors as experimental therapeutics for neurodegenerative disorders

Borders, Aaron S., McNamara, Laurie K., Roy, Saktimayee M., Chico, Laura Wing, Pishchulina, Anna, de Almeida, Lucia M., Van Eldik, Linda J., Watterson, D. Martin

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 55 KB

english, 2008

37

Calcium-Dependent Regulatory Protein of Cyclic Nucleotide Metabolism in Normal and Transformed Chicken Embryo Fibroblasts

D. Martin Watterson, Linda J. Van Eldik, Ralph E. Smith and Thomas C. Vanaman

Journal:

Proceedings of the National Academy of Sciences

Year:

1976

Language:

english

File:

PDF, 1.28 MB

english, 1976

38

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

Webster, Scott J., Bachstetter, Adam D., Nelson, Peter T., Schmitt, Frederick A., Van Eldik, Linda J.

Journal:

Frontiers in Genetics

Year:

2014

Language:

english

File:

PDF, 1.12 MB

english, 2014

39

A dual role for apolipoprotein E in neuroinflammation

Ling Guo, Mary Jo LaDu, Linda J. Van Eldik

Journal:

Journal of Molecular Neuroscience

Year:

2004

Language:

english

File:

PDF, 190 KB

english, 2004

40

Neurotrophic activity of S-100β in cultures of dorsal root ganglia from embryonic chick and fetal rat

Linda J. Van Eldik, Barbara Christie-Pope, Laurel M. Bolin, Eric M. Shooter, William O. Whetsell Jr.

Journal:

Year:

1991

Language:

english

File:

PDF, 3.01 MB

english, 1991

41

Secretion of S-100 from rat C6 glioma cells

Linda J. Van Eldik, Danna B. Zimmer

Journal:

Year:

1987

Language:

english

File:

PDF, 441 KB

english, 1987

42

Vascular neuropathology in dementia patients receiving antipsychotic therapy

Jicha, Gregory, Nelson, Peter, Fardo, David, Kryscio, Richard, Schmitt, Frederick, Smith, Charles, Neltner, Janna, Van Eldik, Linda, Kukull, Walter, Abner, Erin

Journal:

Alzheimer's & Dementia

Year:

2013

Language:

english

File:

PDF, 52 KB

english, 2013

43

[International Review of Neurobiology] Neuroinflammation in Neuronal Death and Repair Volume 82 || Glia Proinflammatory Cytokine Upregulation as a Therapeutic Target for Neurodegenerative Diseases: Function‐Based and Target‐Based Discovery Approaches

Van Eldik, Linda J.

Year:

2007

Language:

english

File:

PDF, 237 KB

english, 2007

44

The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism

Bachstetter, Adam D, Xing, Bin, Van Eldik, Linda J

Journal:

Journal of Neuroinflammation

Year:

2014

Language:

english

File:

PDF, 1.01 MB

english, 2014

45

Validation of the Neuroinflammation Cycle as a Drug Discovery Target Using Integrative Chemical Biology and Lead Compound Development with an Alzheimers Disease-Related Mouse Model

Hu, Wenhui, Ranaivo, Hantamalala, Craft, Jeffrey, Van Eldik, Linda, Watterson, D.

Journal:

Current Alzheimer Research

Year:

2005

Language:

english

File:

PDF, 222 KB

english, 2005

46

A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction

Roy, Saktimayee M, Minasov, George, Arancio, Ottavio, Chico, Laura W, Van Eldik, Linda J., Anderson, Wayne F, Pelletier, Jeffrey C, Watterson, D. Martin

Journal:

Journal of Medicinal Chemistry

Year:

2019

File:

PDF, 3.36 MB

2019

47

Deletion of p38α MAPK in microglia blunts trauma-induced inflammatory responses in mice

Morganti, Josh M., Goulding, Danielle S., Van Eldik, Linda J.

Journal:

Journal of Neuroinflammation

Year:

2019

File:

PDF, 2.19 MB

2019

48

Discovery of a new class of synthetic protein kinase inhibitors that suppress selective aspects of glial activation and protect against β-amyloid induced injury

D. Martin Watterson, Anastasia V. Velentza, Magdalena Zasadzki, Jeffrey M. Craft, Jacques Haiech, Linda J. Van Eldik

Journal:

Journal of Molecular Neuroscience

Year:

2003

Language:

english

File:

PDF, 717 KB

english, 2003

49

Copper-Dependent Formation of Disulfide-Linked Dimer of S100B Protein

In Sook Matsui Lee, Masami Suzuki, Nobuhiro Hayashi, Jingru Hu, Linda J. Van Eldik, Koiti Titani, Morimitsu Nishikimi

Journal:

Archives of Biochemistry and Biophysics

Year:

2000

Language:

english

File:

PDF, 330 KB

english, 2000

50

Calmodulin and rat vitamin D-dependent calcium-binding proteins: Biochemical and immunochemical comparison

Sylvia Christakos, M. Elizabeth, H. Bruns, Aruna S. Mehra, William B. Rhoten, Linda J. Van Eldik

Journal:

Archives of Biochemistry and Biophysics

Year:

1984

Language:

english

File:

PDF, 4.02 MB

english, 1984

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